Structural basis for catalytic activation of protein Z–dependent protease inhibitor (ZPI) by protein Z
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منابع مشابه
Structural basis for catalytic activation of protein Z-dependent protease inhibitor (ZPI) by protein Z.
The anticoagulant serpin, protein Z-dependent protease inhibitor (ZPI), is catalytically activated by its cofactor, protein Z (PZ), to regulate the function of blood coagulation factor Xa on membrane surfaces. The X-ray structure of the ZPI-PZ complex has shown that PZ binds to a unique site on ZPI centered on helix G. In the present study, we show by Ala-scanning mutagenesis of the ZPI-binding...
متن کاملTHROMBOSIS AND HEMOSTASIS Structural basis for catalytic activation of protein Z–dependent protease inhibitor (ZPI) by protein Z
The anticoagulant serpin, protein Z-dependent protease inhibitor (ZPI), is catalytically activated by its cofactor, protein Z (PZ), to regulate the function of blood coagulation factor Xa on membrane surfaces. The X-ray structure of the ZPI-PZ complex has shown that PZ binds to a unique site on ZPI centered on helix G. In the present study, we show by Ala-scanning mutagenesis of the ZPIbinding ...
متن کاملPolymorphisms of the protein Z-dependent protease inhibitor (ZPI) gene and the risk of venous thromboembolism.
Thromb Haemost 2006; 95: 909–10 Dear Sir, Protein Z-dependent protease inhibitor (ZPI), together with its cofactor protein Z (PZ), inhibits activated factor Xa (Xa) (1–3). Studies in mice showed that the PZ null genotype increases the mortality in utero of homozygous factor V Leiden mice due to vascular thrombosis and hepatic fibrin deposition (4), suggesting a role for the PZ-ZPI pathway in th...
متن کاملThe protein Z/protein Z-dependent protease inhibitor complex.
Protein Z (PZ) is a vitamin K-dependent factor identified in human plasma in 1984 but it has no enzymatic activity. It is a cofactor of a serpin, the protein Z-dependent protease inhibitor (ZPI), and the complex PZ/ZPI inhibits activated factor X on phospholipid surfaces. In mice, the disruption of PZ or ZPI gene is asymptomatic, but enhances the thrombotic phenotype and mortality of other thro...
متن کاملProtein Z and protein Z-dependent protease inhibitor. Determinants of levels and risk of venous thrombosis.
To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ an...
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ژورنال
عنوان ژورنال: Blood
سال: 2012
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2012-03-419598